05-26-2024, 04:27 PM
Another upcoming paper...No data uploaded yet unfortunately though.
ENA: https://www.ebi.ac.uk/ena/browser/view/PRJEB75495
"Repeated Plague Infections Across Six Generations of Neolithic Farmers" -
"In the period between 5,300 and 4,900 years before present (cal. BP), populations across large parts of Europe underwent a period of demographic decline. However, the cause of this so-called Neolithic decline is still debated. Some argue for an agricultural crisis resulting in the decline, others for the spread of an early form of plague. Here, we use population-scale ancient genomics to infer ancestry, social structure and pathogen infection in 108 Scandinavian Neolithic individuals from eight megalithic graves and a stone cist. We find that the Neolithic plague was widespread, detected in at least 17% of the sampled population and across large geographical distances. We demonstrate that the disease spread within the Neolithic community in three distinct infection events within a period of around 120 years. Variant graph-based pan-genomics reveals that the Neolithic plague genomes retained ancestral genomic variation present in Yersinia pseudotuberculosis, including virulence factors associated with disease outcomes. Additionally, we reconstruct four multi-generation pedigrees, the largest of which consists of 38 individuals spanning six generations, showing a patrilineal social organisation. Lastly, we document direct genomic evidence for Neolithic female exogamy in a woman buried in a different megalithic tomb than her brothers. Taken together, our findings provide a detailed reconstruction of plague spread within a large patrilineal kinship group and identify multiple plague infections in a population dated to the beginning of the Neolithic Decline."
ENA: https://www.ebi.ac.uk/ena/browser/view/PRJEB75495
"Repeated Plague Infections Across Six Generations of Neolithic Farmers" -
"In the period between 5,300 and 4,900 years before present (cal. BP), populations across large parts of Europe underwent a period of demographic decline. However, the cause of this so-called Neolithic decline is still debated. Some argue for an agricultural crisis resulting in the decline, others for the spread of an early form of plague. Here, we use population-scale ancient genomics to infer ancestry, social structure and pathogen infection in 108 Scandinavian Neolithic individuals from eight megalithic graves and a stone cist. We find that the Neolithic plague was widespread, detected in at least 17% of the sampled population and across large geographical distances. We demonstrate that the disease spread within the Neolithic community in three distinct infection events within a period of around 120 years. Variant graph-based pan-genomics reveals that the Neolithic plague genomes retained ancestral genomic variation present in Yersinia pseudotuberculosis, including virulence factors associated with disease outcomes. Additionally, we reconstruct four multi-generation pedigrees, the largest of which consists of 38 individuals spanning six generations, showing a patrilineal social organisation. Lastly, we document direct genomic evidence for Neolithic female exogamy in a woman buried in a different megalithic tomb than her brothers. Taken together, our findings provide a detailed reconstruction of plague spread within a large patrilineal kinship group and identify multiple plague infections in a population dated to the beginning of the Neolithic Decline."