05-06-2024, 09:17 AM
Cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia
Abstract
Previous genomic studies understanding the dispersal of Homo sapiens have suggested that present-day East Eurasians and Native Americans can trace their ancestry to migrations from Southeast Asia. However, ineluctable adaptations during the Last Glacial Maximum (LGM) remain unclear. By analyzing 42 genomes of up to 30-fold coverage from prehistoric hunter-gatherers, Jomon, we reveal their descent from Upper Paleolithic (UP) foragers who migrated to and isolated in the Japanese archipelago during Late Pleistocene. We provide compelling evidence suggesting that these UP people underwent positive selection for cold environments, aiding their survival through the LGM facilitated by non-shivering thermogenesis and detecting it polygenically across multiple loci in the Jomon lineage. Our study pioneers the close estimation of the physiological adaptation of ancient humans by the paleogenomic approach.
https://www.biorxiv.org/content/10.1101/...91810v1?ct=
Could not find the data but it should be available at some point.
All raw genomic data (fastq files) are available for download in the DNA DataBank of
Japan (DDBJ) Sequence Read Archive (DRA. https://www.ddbj.nig.ac.jp/index-e.html)
under the accession numbers PRJDB14637, PRJDB18003 and PRJDB18005.
Abstract
Previous genomic studies understanding the dispersal of Homo sapiens have suggested that present-day East Eurasians and Native Americans can trace their ancestry to migrations from Southeast Asia. However, ineluctable adaptations during the Last Glacial Maximum (LGM) remain unclear. By analyzing 42 genomes of up to 30-fold coverage from prehistoric hunter-gatherers, Jomon, we reveal their descent from Upper Paleolithic (UP) foragers who migrated to and isolated in the Japanese archipelago during Late Pleistocene. We provide compelling evidence suggesting that these UP people underwent positive selection for cold environments, aiding their survival through the LGM facilitated by non-shivering thermogenesis and detecting it polygenically across multiple loci in the Jomon lineage. Our study pioneers the close estimation of the physiological adaptation of ancient humans by the paleogenomic approach.
https://www.biorxiv.org/content/10.1101/...91810v1?ct=
Could not find the data but it should be available at some point.
All raw genomic data (fastq files) are available for download in the DNA DataBank of
Japan (DDBJ) Sequence Read Archive (DRA. https://www.ddbj.nig.ac.jp/index-e.html)
under the accession numbers PRJDB14637, PRJDB18003 and PRJDB18005.